If you need a specific file extension to open in a native application you can create the association with the cxwinassoc tool. For example if you're using IE7 and you click a PDF document IE will complain it can't open that file (Acrobat isn't installed) even if you have Acrobat installed in the native Linux OS. You can create a mapping from Crossover to the native program by opening a terminal and running
cxoffice/bin/cxwinassoc --bottle bottlename --extension .xxx /path/to/tool
How can I get Crossover to recognize new fonts added to a bottle?
Why do my CrossOver applications report time a hour faster or slower than my system?
Open an .exe in cxrun by double-clicking.
Reset the DPI using Wine Configuration